In - vitro antioxidant and antibacterial activities of the four synthesized indole derivatives

The indole nucleus seems to be a promising basis for design and synthesis of new derivatives able to protect oxidative stress in a variety of acute and chronic pathologies. The paper presents an overview of indole derived compounds in which inhibitory action has been demonstrated against potent microbes and also tested for antioxidant activity. Cellular damage caused by reactive oxygen species has been implicated in several diseases and hence antioxidants have significant importance in human health. In vitro evaluation of antioxidant and antibacterial potentials of the four compounds viz. I1, I2, I3 and I4 showed significant results. Compound I4 showed promising results for reducing power, hydroxyl free radical and superoxide scavenging assays when compared with standard drug. The same showed highest inhibitory activity against Gram positive organism, where as I1 showed least effect and I2, I3 were moderate in both the activities. Eventhough all the four compounds are indole derivatives, their change in the potencies may be due to the structural differences.